|
KMID : 1134819990280061349
|
|
Journal of the Korean Society of Food Science and Nutrition
1999 Volume.28 No. 6 p.1349 ~ p.1354
|
|
|
Effect of Korean Red Ginseng on Clinical Chemical Parameters in Male Guinea Pigs Exposed Acutely to 2,3,7,8 - Tetrachlorodibenzo - p - dioxin
|
|
Hwang Seock-Yeon
Kim Si-Kwan
Kim Shin-Hee
Kwak Yi-Seong
Chung Young-Jin
|
|
|
Abstract
|
|
|
|
This study was carried out to investigate the protective effect of Korean red ginseng water extract (KRG-WE) on clinical chemical parameters in male guinea pigs acutely exposed to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin(TCDD). Forty male guinea pigs(200±20g) were divided into 4 groups. Normal controls(group 1) received vehicle and saline; group 2(single TCDD-treated) received TCDD(5㎍/㎏, single dose) intraperitoneally; group 3 received KRG-WE(200㎍/㎏, i.p.) for 2 weeks from 1 week before TCDD-exposure; group 4 received KRG-WE for 1 week since the day of TCDD-exposure. Increase in body weight was retarded greatly by TCDD-exposure. Body weight of animals in group 2 was significantly decreased starting 2 days after TCDD-exposure. However, body weight of animals in group 3 increased throughout the experimental period, although the increasing rate was slower than that of group 1. Decrease in body weight was not observed during the experimental period in group 4. Increases in blood glucose, amylase, lipase, total cholesterol, triglyceride, GOT, GPT, and LDH levels by TCDD intoxication were significantly attenuated by the KRG-WE treatment(p＜0.05). These results provide a strong evidence that Korean red ginseng might be a useful protective agent against TCDD, an endocrine disruptor.
|
|
|
KEYWORD
|
|
|
dioxin, ginseng, clinical chemical paramenters, protection
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|